Mechanisms driving chromosomal translocations: lost in time and space
نویسندگان
چکیده
منابع مشابه
Mechanisms of Recurrent Chromosomal Translocations
Chromosomal translocations frequently involve fusion of the ends of two separate DNA double-stranded breaks (DSBs) at distinct genomic locations. Recurrent chromosomal translocations are found in various cancers. Recently developed high-throughput approaches to clone genome-wide translocations that involve site-specifi c DSBs have provided new insights into mechanisms of chromosomal translocati...
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Recurrent chromosomal translocations are characteristic features of many types of cancers, especially lymphomas and leukemias. Several basic mechanistic factors are required for the generation of most translocations. First, DNA double-strand breaks (DSBs) must be present simultaneously at the two participating loci. Second, the two broken loci must either be in proximity or be moved into proxim...
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The most significant complication of pregnancy is recurrent miscarriage. Numerous factors have been described as associations with recurrent wastage such as: uterine abnormalities, immunological factors, endocrinologic imbalance and chromosomal defects. Cytogenetic evaluation of couples with recurrent pregnancy losses is performed on the basis of G-banding technique only after other possible et...
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Activation-induced deaminase initiates three different antibody diversification reactions: class switch recombination, somatic hypermutation (SHM), and gene conversion. We have shown that, in addition to antibody diversification, activation-induced deaminase can also initiate Burkitt's lymphoma-like c-myc/IgH translocations. However, distinct DNA damage- and oncogene-induced checkpoints operate...
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The malignant cells in many patients who have leukemia, lymphoma, or another hematologic neoplasm have acquired clonal chromosomal abnormalities. Specific cytogenetic abnormalities are closely, and sometimes uniquely, associated with morphologically and clinically distinct subsets of leukemia or lymphoma (1,2). The detection of a cytogenetic abnormality clearly distinguishes between benign reac...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2021
ISSN: 0950-9232,1476-5594
DOI: 10.1038/s41388-021-01856-9